Nucleophilic fluorination of beta-ketoester derivatives with HBF4

[摘要]：Treating readily available alpha-diazo-beta-ketoesters with HBF4 results in nucleophilic fluorination by the usually inert and stable tetrafluoroborate anion. The resulting alpha-fluoro-beta-ketoesters are highly versatile synthetic intermediates, for example in the preparation of fluoro-heterocycles, as illustrated by the direct formation of fluoro-pyrimidines, -pyrazoles and -coumarins in a single step.

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