A biocatalytic hydrogenation of carboxylic acids

[摘要]：The hyperthermophile Pyrococcus furiosus catalyses the hydrogenation of a broad range of carboxylic acids selectively to the corresponding primary alcohols. Other functional groups such as isolated CQC-double bonds are not touched. The chemo-selectivity of the carboxylate reduction may be directed towards aldehydes by simple medium engineering.

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