Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O-6-methyl-2 '-deoxyguanosine and their recognition by MGMT and Atl1

[摘要]：We show that DNA containing a conformationally-locked anti analogue of O-6-alkylguanine is a poor substrate for human O-6-methylguanine-DNA methyltransferase (MGMT) and the alkyltransferase-like protein, Atl1. This highlights the requirement for the syn conformation and rationalises why certain O-6-alkylguanines are poor MGMT substrates.

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