Identification of Amides as Carboxylic Acid Surrogates for Quinolizidinone-Based M-1 Positive Allosteric Modulators

[摘要]：Selective activation of the M-1 muscarinic receptor via positive allosteric modulation represents an approach to treat the cognitive decline in patients with Alzheimer's disease. A series of amides were examined as a replacement for the carboxylic acid moiety in a class of quinolizidinone carboxylic acid M-1 muscarinic receptor positive allosteric modulators, and leading pyran 4o and cyclohexane 5c were found to possess good potency and in vivo efficacy.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内