Versatile Synthesis of Dissymmetric Diarylideneacetones via a Palladium-Catalyzed Coupling-Isomerization Reaction

[摘要]：As a twofold Michael system, the diarylideneacetone core is of particular interest in organic synthesis and for therapeutic applications. To overcome the drawbacks of the classical Claisen-Schmidt protocol, a new methodology for the synthesis of dissymmetric (hetero)diarylideneacetones has been developed. Conditions were optimized with a Box-Behnken design of experiment. The milder reaction conditions allow the efficient preparation of fluorinated, or heteroaromatic, dissymmetric diarylideneacetones which cannot be obtained through the classical Claisen-Schmidt protocol.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内