Novel One-Pot Synthesis of 2-Substituted 3-Alkoxyisoindolin-1-imine Derivatives from 2-Cyanobenzaldehyde, Amine, and Alcohol

[摘要]：A novel, one-pot procedure has been developed for the synthesis of 2-substituted 3-alkoxyisoindolin-1-imine derivatives via three-component condensation of 2-cyanobenzaldehyde, amine, and alcohol. The efficient and convenient reaction conditions provide the corresponding products from various substrates in good yields (65-96%) catalyzed by acetic acid. The straightforward procedure is a valid contribution to methods for the synthesis of isoindolin-1-imine derivatives.

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