Enantioselective Synthesis of beta-Aryloxycarboxylic Esters via Asymmetric Hydrogenation of beta-Aryloxy-alpha,beta-Unsaturated Esters

[摘要]：A novel synthesis of beta-aryloxycarboxylic esters via asymmetric hydrogenation of the corresponding beta-aryloxy-alpha,beta-unsaturated esters has been demonstrated. Bis(norbornadiene)rhodium(I) tetrafluoroborate (1 mol %) and Walphos W008-1 were used to generate the saturated products with high enantioselectivity and in high yield. The tolerability of the reaction to a diverse range of substituents on the aromatic ring was also explored.

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