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A Synthetic Receptor for Nicotine from a Dynamic Combinatorial Library

  作者 HAMIEH SALEH; LUDLOW R FREDERICK; PERRAUD OLIVIER; WEST KEVIN R; MATTIA ELIO; OTTO SIJBREN  
  选自 期刊  Organic Letters;  卷期  2012年14-21;  页码  5404-5407  
  关联知识点  
 

[摘要]Designing synthetic receptors that bind biologically relevant guests in an aqueous solution remains a considerable challenge. We now report a new synthetic receptor for nicotine, selected from a dynamic combinatorial library, that binds this guest in water at neutral pH through a combination of hydrophobic and pi-pi a interactions.

 
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