Solvent-Free Synthesis of 2-(Phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine Derivatives Catalyzed by Sulfamic Acid

[摘要]：A series of 2-(phenylamino)-4-(trifluoromethyl)-1,6-dihydropyrimidine derivatives were synthesized efficienly via the reaction of aryl aldehyde, ethyl 4,4,4-trifluoro-3-oxobutanoate and 1-phenylguanidine carbonate catalyzed by sulfamic acid under solvent-free conditions. This protocol has the advantages of mild condition, high yields and environmentally benign procedure.

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