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[摘要]：We evaluated the potential of apple to reduce inflammation. Phenolic compounds and triterpenes were analyzed in 109 apple cultivars. Total phenolics ranged from 29 to 7882 mu g g(-1) of fresh weight (FW) in the flesh and from 733 to 4868 mu g g(-1) FW in the skin, with flavanols including epicatechin and procyanidins as major components. Ursolic (44.7 to 3522 mu g g(-1) FW) and oleanolic (47.2 to 838 mu g g(-1) FW) acids dominated the skin triterpene profile. Five chemically contrasting cultivars were fractionated and their immune-modulating activity measured using two cell-based assays targeting key points in the inflammation process. Cultivars exhibiting high contents of procyanidins were the most potent at inhibiting NF-kappa B while triterpene-rich fractions reduced the promoter activity of the gene of TNF alpha. This study provides new insights into how apple genetic diversity could be used to alleviate inflammation. |
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