I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

[摘要]：I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-1 alpha promoter sequence shows unexpected stability near neutral pH.

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