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A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy

  作者 XIAO HAIHUA; YAN LESAN; ZHANG YU; QI RUOGU; LI WENLIANG; WANG RUI; LIU SHI; HUANG YUBIN; LI YUXIN; JING XIABIN  
  选自 期刊  Chemical Communications;  卷期  2012年48-87;  页码  10730-10732  
  关联知识点  
 

[摘要]A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.

 
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