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[摘要]:A new synthetic route for biologically interesting pyranocarbazoles was developed by reaction of 2- or 4-hydroxycarbazole with alpha,beta-unsaturated aldehydes in the presence of ethylenediamine diacetate (EDDA). The key strategy of this methodology is a formal [3+3] cycloaddition via domino aldol-type/6 pi-electrocyclization. The synthesized pyranocarbazoles can be converted into derivatives bearing substituents on the carbazole and pyran rings. |
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