Investigation of an Acrylate Lynchpin Approach toward the Synthesis of Stolonidiol

[摘要]：An acrylate lynchpin approach toward the synthesis of stolonidiol has been investigated. To access the key macrocyclization precursor we adapted the silylcupration reaction of alkynes, facilitating attack of the intermediate vinylcuprate on a trisubstituted epoxide. With all of the required carbons of stolonidiol in place, macrocyclization reactions to provide the 11-membered ring were attempted using either a nickel-mediated cyclization of a bromo aldehyde, intercepting methyl acrylate, or an intramolecular Baylis-Hillman cyclization.

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