Enantioselective Organocatalytic Thiol Addition to alpha,beta-Unsaturated alpha-Amino Acid Derivatives

[摘要]：A new class of Michael acceptors based on alpha,beta-unsaturated amino acids has been prepared and applied in asymmetric organocatalysis. With the use of thiourea derivatives of cinchona alkaloid-derived catalysts, efficient addition of thiols to the dehydroamino acids occurred with formation of beta-thiol functionalized alpha-amino acids in high yields, moderate diastereoselectivities and ee values up to 95%.

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