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Tandem Ring-Opening Decarboxylation of Cyclopropane Hemimalonates with Sodium Azide: A Short Route to gamma-Aminobutyric Acid Esters

  作者 EMMETT MICHAEL R; GROVER HUCK K; KERR MICHAEL A  
  选自 期刊  Journal of Organic Chemistry;  卷期  2012年77-15;  页码  6634-6637  
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[摘要]Cyclopropane hemimalonates, when treated with sodium azide, undergo a tandem ring-opening decarboxylation to produce gamma-azidobutyric acids in good yields. These adducts were hydrogenated to form gamma-aminobutyric acid (GABA) methyl esters.

 
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