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A Five-Step Synthesis of (+/-)-Tylophorine via a Nitrile-Stabilized Ammonium Ylide

  作者 LAHM GUENTHER; STOYE ALEXANDER; OPATZ TILL  
  选自 期刊  Journal of Organic Chemistry;  卷期  2012年77-15;  页码  6620-6623  
  关联知识点  
 

[摘要]The Stevens rearrangement of a nitrile-stabilized ammonium ylide is the key step of a very short and practical synthesis of the phenanthroindolizine alkaloid (+/-)-tylophorine. The method requires only five linear steps and is devoid of any protecting group manipulations.

 
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