Enantioselective Synthesis of a Dual Orexin Receptor Antagonist

[摘要]：A concise, enantioselective synthesis of the potent dual orexin inhibitor suvorexant (1) is reported. Key features of the synthesis include a mild copper-catalyzed amination, a highly chemoselective conjugate addition, and a tandem enantioselective transamination/seven-membered ring annulation. The synthesis requires inexpensive starting materials and only four linear steps for completion.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内