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Solid-Phase Synthesis of gamma-AApeptides Using a Submonomeric Approach

  作者 WU HAIFAN; AMIN MOHAMED NASSIR; NIU YOUHONG; QIAO QIAO; HARFOUCH NASSIER; NIMER ABDELFATTAH; CAI JIANFENG  
  选自 期刊  Organic Letters;  卷期  2012年14-13;  页码  3446-3449  
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[摘要]The solid-phase synthesis of gamma-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing gamma-AApeptide building blocks in order to prepare gamma-AApeptide sequences. This method will maximize the potential of developing chemically diverse gamma-AApeptide libraries and thereby facilitate the biological applications of gamma-AApeptides in the future.

 
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