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A Diels-Alder-Based Total Synthesis of (-)-Kainic Acid

  作者 ORELLANA ARTURO; PANDEY SUSHIL K; CARRET SEBASTIEN; GREENE ANDREW E; POISSON JEANFRANCOIS  
  选自 期刊  Journal of Organic Chemistry;  卷期  2012年77-12;  页码  5286-5296  
  关联知识点  
 

[摘要]An efficient synthesis of (-)-kainic acid, through a high-pressure-promoted Diels-Alder cycloaddition of a vinylogous malonate derived from 4-hydroxyproline, is described. The bicyclic adduct could be converted into the natural product with complete stereocontrol.

 
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