[摘要]：2'-O-[N-(4-Aminobutylcarbamoyl)]uridine (U-abcm) was synthesized and incorporated into oligonucleotides. The oligonucleotides incorporating U-abcm formed more stable duplexes with their complementary and mismatched RNAs than those containing 2'-O-carbamoyluridine (U-cm). The stability of duplex with a U-abcm-rG base pair showed higher thermostability than the duplex having unmodified U-rG base pair. The U-abcm residue showed enhanced resistance to snake venome phosphodiesterase. (C) 2012 Elsevier Ltd. All rights reserved.
