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Synthesis of N-Alkoxycarbonyl Ketimines Derived from Isatins and Their Application in Enantioselective Synthesis of 3-Aminooxindoles

  作者 YAN WENJIN; WANG DONG; FENG JINGCHAO; LI PENG; ZHAO DEPENG; WANG RUI  
  选自 期刊  Organic Letters;  卷期  2012年14-10;  页码  2512-2515  
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[摘要]A simple and general method in the synthesis of N-alkoxycarbonyl ketimines derived from isatins has been described first. Generally, the enantioselective addition of 1,3-dicarbonyl compounds to this kind of ketimine affords chiral 3-amino oxindoles in high yield and excellent ee.

 
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