【文章名】Improved In Vitro Dissolution Parameters and In Vivo Hypolipidemic Efficiency of Atorvastatin Calcium Through the Formation of Hydrophilic Inclusion Complex With Cyclodextrins
Improved In Vitro Dissolution Parameters and In Vivo Hypolipidemic Efficiency of Atorvastatin Calcium Through the Formation of Hydrophilic Inclusion Complex With Cyclodextrins
作者
Hussein, AK; Ibrahim, MA; Amin, MA; Ahmed, OAA; Afouna, MI
[摘要]:An aim of the present study was to improve the dissolution of the inherently low water solubility hypolipidemic agent, Atorvastatin calcium (ATC), through the preparation and characterization of ATC with cyclodextrins (CDs) inclusion complexes employing d