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Antiproliferative Acetogenins from a Uvaria sp from the Madagascar Dry Forest

  作者 Dai, YM; Harinantenaina, L; Brodie, PJ; Callmander, MW; Randrianaivo, R; Rakotonandrasana, S; Rakotobe, E; Rasamison, VE; Shen, YC; TenDyke, K; Suh, EM; Kingston, DGI  
  选自 期刊  Journal of natural products;  卷期  2012年75-3;  页码  479-483  
  关联知识点  
 

[摘要]Investigation of the endemic Madagascan plant Uvaria sp. for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of two new acetogenins. The structures of these two compounds were elucidated on the basis of analysis of their 1D and 2D NMR spectra, circular dichroism, and mass spectrometric data, together with chemical modification. The two acetogenins display weak antiproliferative activity against the A2780 ovarian cancer, the A2058 melanoma, and the H522 lung cancer cell lines.

 
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