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Selenoprotein K Binds Multiprotein Complexes and Is Involved in the Regulation of Endoplasmic Reticulum Homeostasis

  作者 Shchedrina, VA; Everley, RA; Zhang, Y; Gygi, SP; Hatfield, DL; Gladyshev, VN  
  选自 期刊  Journal of Biological Chemistry;  卷期  2011年286-50;  页码  42937-42948  
  关联知识点  
 

[摘要]Background: Selenoprotein K (SelK) is an endoplasmic reticulum (ER) protein of unknown function. Results: SelK associates with proteins involved in elimination of misfolded proteins from the ER. Conclusion: SelK is a functional component of ER homeostasis. Significance: This study defines a new family of selenoproteins and links it to an ER-associated degradation.

 
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