[摘要]:Background: The vesicular nucleotide transporter (VNUT) transports nucleotides in the presence of Mg(2+). Results: VNUT transports divalent cations in a membrane potential-and nucleotide-dependent manner. Conclusion: VNUT transports divalent cations as a nucleotide complex. Significance: VNUT functions as a divalent cation importer in secretory vesicles.