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[摘要]：Three new neolignans, (7S,8S,7'E)-4,9-dihydroxy-3,7,3',9'-tetramethoxy-8,4'-oxyneolign-7'-ene (1), (7R,8S,7'E)-4, 9-dihydroxy-3,7,3', 9'-tetramethoxy-8,4'-oxyneolign-7'-ene (2), (7S,8S,7'E)-5, 9-dihydroxy-3,7,3',5',9'-pentamethoxy-8,4'-oxyneolign-7'-ene (3), and one new phenylpropanoid, threo-5-hydroxy-3,7-dimethoxyphenylpropane-8,9-diol (4), were isolated from the leaves and stems of Toona ciliata var. pubescens. Their structures were determined on the basis of spectroscopic analysis, especially 2D-NMR, HR-ESI-MS, and CD data. The antiproliferative activities of these compounds against four tumor cell lines (A549, Colo 205, QGY-7703, and LOVO) were also evaluated by MTT (=(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method. |
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