[摘要]：An efficient and short total synthesis of (-)-cleistenolide (1) from D-mannitol with an overall yield of 23.6% is described. The chiron approach for the synthesis of (-)-cleistenolide involves a one-C-atom Wittig olefination, a selective allylic triethylsilyl protection, and a Grubbs-catalyzed ring-closure-metathesis (RCM) reaction as the key steps.
