Releasing a tiny molecular brake may improve memory

[摘要]：Understanding the molecular pathways underlying cognitive decline during neurodegenerative diseases is essential to design effective therapeutic strategies. In this issue of The EMBO Journal, Zovoilis et al identify miR-34c as a hippocampal-specific microRNA up-regulated in ageing and neurodegeneration. Cognitive deficits in aged mice and Alzheimer mouse models could be rescued by inhibiting miR-34c or by preventing the interaction between miR-34c and its target SIRT1. Thus, miR-34c might be both a marker for the onset of memory impairments and a promising target for therapeutic approaches in dementia.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内