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The Decarboxylative Strecker Reaction

  作者 DAS DEEPANKAR; RICHERS MATTHEW T; MA LONGLE; SEIDEL DANIEL  
  选自 期刊  Organic Letters;  卷期  2011年13-24;  页码  6584-6587  
  关联知识点  
 

[摘要]alpha-Amino acids react with aldehydes in the presence of a cyanide source to form alpha-amino nitriles in what can be considered a decarboxylative variant of the classical Strecker reaction. This unprecedented transformation does not require the use of a metal catalyst and provides facile access to valuable alpha-amino nitrites that are inaccessible by traditional Strecker chemistry.

 
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