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Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

作者	Zhang, XQ; Hufnagel, H; Hou, CF; Opas, E; McKenney, S; Crysler, C; O'Neill, J; Johnson, D; Sui, ZH

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2011年21-20; 页码 6042-6048

关联知识点

[摘要]：A novel series of 4-azetidinyl-1-aryl-cyclohexanes containing indazole or benzoisoxazole moiety have been identified as potent CCR2 antagonists with high selectivity versus hERG. (C) 2011 Elsevier Ltd. All rights reserved.
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