Bioactive sulfoximines: Syntheses and properties of Vioxx (R) analogs

[摘要]：The syntheses and biological profiles of sulfoximine-based Vioxx (R) analogs 2 are described. Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx (R) itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (R) (1). (C) 2011 Elsevier Ltd. All rights reserved.

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