Synthesis and cytotoxicity of the depsipeptides analogues of callipeltin B

[摘要]：Solid phase synthesis of the cyclic depsipeptides of callipeltin B analogues and evaluation of cytotoxicity of synthetic peptides are described. We attempted to synthesize cyclic depsipeptides via the esterification or the amide bond formation for cyclization steps. In the assay of synthetic peptides, the linear peptide (10) exhibited modest cytotoxicity against HeLa cells. (C) 2011 Elsevier Ltd. All rights reserved.

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