Enantioselective Syntheses of (+)-Sertraline and (+)-Indatraline Using Lithiation/Borylation-Protodeboronation Methodology

[摘要]：The lithiation/borylation-protodeboronation of a homoallyl carbamate was applied to the synthesis of (+)-sertraline and (+)-indatraline. Due to the presence of the alkene, significant modifications of the methodology were required (use of 12-crown-4, TMSCI, H(2)O), or a solvent switch to CHCI(3), to achieve high yields and high selectivities.

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