Stereoselective Synthesis of Isoxazolinobenzoxepanes via Intramolecular Nitrile Oxide Cycloaddition

[摘要]：Concise routes to the synthesis of indole-tethered nitrile oxides have been developed, and their intramolecular nitrile oxide cycloadditions were studied. Heterocyclic scaffolds involving isoxazolinobenzoxepane frameworks have been achieved via intramolecular nitrile oxide cycloaddition of 3-[1-(2-allyloxyphenyl)-2-nitroethyl]-1H-indole derivatives using (Boc)(2)O and DMAP. This protocol affords products with excellent trans-selectivity.

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