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ESTROGEN RECEPTOR alpha/beta LIGANDS DERIVED FROM THALIDOMIDE

  作者 NOGUCHIYACHIDE TOMOMI; SUGITA KAZUYUKI; HASHIMOTO YUICHI  
  选自 期刊  Heterocycles;  卷期  2011年83-9;  页码  2137-2147  
  关联知识点  
 

[摘要]We have developed a series of thalidomide-derived phthalimide-type estrogen receptor (ER) modulators with characteristic subtype (ER alpha/ER beta) selectivity, and investigated their structure-activity relationship for ER agonistic and antagonistic activities.

 
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