ONE-POT SYNTHESIS OF DIHYDROPYRIMIDIONES VIA ENVIRONMENTALLY FRIENDLY ENZYME-CATALYZED BIGINELLI REACTION

[摘要]：A novel enzyme-catalyzed Biginelli reaction of acetoacetate, aromatic aldehyde and urea (thiourea) was described. Great acceleration of the one-pot multicomponent reaction was observed by the aid of enzymes. Various dihydropyrimidiones were prepared in good yields under the conditions using trypsin from porcine pancreas as the catalyst.

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