SYNTHESIS OF IMIDAZOLE C(1)- AND C(3)-RIBONUCLEOSIDE PHOSPHORAMIDITES FOR PROBING CATALYTIC MECHANISM IN RIBOZYME

[摘要]：Synthesis of C4-linked imidazole N-pivaloyloxymethyl (P0M)-2'-O-cyanoethylated (CE) C(1)- and C(3)-ribonucleoside phosphoramidites 1a and 1b is described. These phosphoramidite products were incorporated into RNA sequence through solid phase phosphoramidite approach, providing RNA with imidazole linked through different length to sugar residue, to study the mechanism of a ribozyme.

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