Selective Synthesis of New Fluorinated Alicyclic beta-Amino Ester Stereoisomers

[摘要]：New fluorinated alicyclic beta-amino ester stereoisomers with a cyclohexene or cyclohexane skeleton were prepared from cis- or trans-2-aminocyclohex-3-enecarboxylic acids in five or six steps through a regio- and stereoselective hydroxylation and hydroxy-fluorine exchange. Fluorinated amino ester enantiomers were synthesized from enantiopure cis- or trans-2-aminocyclohexenecarboxylic acid (prepared by enzymatic resolution of the racemic substances).

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