Light-controlled DNA binding of bisbenzamidines

[摘要]：Caging of the amidinium moieties of two representative bisbenzamidine DNA binders with suitable photoresponsive protecting groups suppresses their DNA-binding, which can then be fully recovered upon irradiation with UV light that removes the caging groups, regenerating the parent compounds. Moreover, a caged aza-pentamidine ((c) 1a) is inert against Candida albicans, but displays a potent growth inhibitory activity after irradiation with UV light.

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