High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity

[摘要]：Glycosylated analogues of novobiocin, discovered using a broad library of enzymes, have 100-fold improved activity against breast, brain, pancreatic, lung and ovarian cancers and ablated associated off-target activity leading to an up to 2.7 x 10(4) fold increase in selectivity.

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