A Novel Synthesis of Isoflavones via Copper(I)-Catalyzed Intramolecular Cyclization Reaction

[摘要]：Isoflavone derivatives were synthesized via intramolecular cyclization of 3-(2-bromophenyl)-3-oxopropanal derivatives, using CuI as the catalyst, 2-picolinic acid (= pyridine-2-carboxylic acid) as the ligand, K2CO3 as the base, and DMF as the solvent, in up to 96% yield. The synthesis is functional group-tolerant.

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