Synthesis of 1,2,3-Triazole Elements in Histamine H(3) Receptor Ligands

[摘要]：1,2,3-Triazole moieties were introduced in a histamine H(3) receptor antagonist pharmacophore blueprint with a versatile click chemistry approach, yielding potent ligands. Azide and alkynes were combined under copper(I) catalysis to provide the triazole element. Conventional synthesis, as well as microwave irradiation, was successfully applied.

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