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[摘要]:A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum In vitro, was isolated from the flowers of Cassia siamea, and Its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben-Hoesch type ring construction as key steps. |
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