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Total Synthesis of A Novel Tetracyclic Alkaloid, Cassiarin F from the Flowers of Cassia siamea

  作者 DEGUCHI JUN; HIRAHARA TOMOE; OSHIMI SHIORI; HIRASAWA YUSUKE; EKASARI WIWIED; SHIROTA OSAMU; HONDA TOSHIO; MORITA HIROSHI  
  选自 期刊  Organic Letters;  卷期  2011年13-16;  页码  4344-4347  
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[摘要]A novel alkaloid, cassiarin F (1), which showed potent antiplasmodial activity against Plasmodium falciparum In vitro, was isolated from the flowers of Cassia siamea, and Its structure was elucidated on the basis of 2D NMR analyses. A total synthesis of 1 was also achieved by employing the Suzuki coupling constructing biaryl unit, nucleophilic aromatic substitution, and Houben-Hoesch type ring construction as key steps.

 
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