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Total synthesis of (-)-nakadomarin A

  作者 KYLE ANDREW F; JAKUBEC PAVOL; COCKFIELD DANE M; CLEATOR ED; SKIDMORE JOHN; DIXON DARREN J  
  选自 期刊  Chemical Communications;  卷期  2011年47-36;  页码  10037-10039  
  关联知识点  
 

[摘要]A highly diastereoselective bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, a furan N-acyliminium cyclisation, a sequential alkyne RCM/syn-reduction and an alkene RCM has allowed a 19 step, highly stereoselective synthesis of (-)-nakadomarin A.

 
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