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[摘要]：Transforming growth factor beta (TGF beta) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGF beta signaling maintains epithelial homeostasis, dysregulated TGF beta signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGF beta signaling in epithelial cells causes hyperproliferation, reduced apoptosis and increased genomic instability, and the compensatory increase in TGF beta production by tumor epithelial cells with TGF beta signaling defects further promotes tumor growth and metastases by increasing angiogenesis and inflammation in tumor stromal cells. Here, we review the mouse models that we used to study TGF beta signaling in HNSCC. Oncogene (2010) 29, 5437-5446; doi:10.1038/onc.2010.306; published online 2 August 2010 |
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