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Isoflavone Dimers and Other Bioactive Constituents from the Figs of Ficus mucuso

  作者 Bankeu, JJK; Khayala, R; Lenta, BN; Noungoue, DT; Ngouela, SA; Mustafa, SA; Asaad, K; Choudhary, MI; Prigge, ST; Hasanov, R; Nkengfack, AE; Tsamo, E; Ali, MS  
  选自 期刊  Journal of natural products;  卷期  2011年74-6;  页码  1370-1378  
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[摘要]Phytochemical investigation of the figs of Ficus mucuso led to the isolation of three new isoflavone dimer derivatives, mucusisoflavones A C (1-3), together with 16 known compounds. Some of the isolates were tested in vitro for their inhibitory properties toward beta-glucuronidase and Plasmodium falciparum enoyl-ACP reductase (PfENR) enzymes. Compound 1 (ICso 0.68 mu M) showed inhibitory activity on beta-glucuronidase enzyme, while 3 (ICso 7.69 mu M) exhibited a weak inhibitory activity against P. falciparum enoyl-ACP reductase (PfENR).

 
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