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[摘要]：Two new biologically active polyoxygenated sterols, 3,5,9-trihydroxycholest-7-en-6-one (1) and cholest-7-ene-3,6,9-triol (3), together with one known sterone, topsentisterol D3 (2), were isolated from freshwater clam (Corbicula fluminea Muller; an important cultured edible shellfish in Taiwan). The structure elucidation of sterols 1 - 3 were accomplished by H-1- and C-13-NMR, HMQC, and HMBC, and MS analyses. The sterols 1 - 3 displayed cytotoxicities against the human hepatoma Hep G2 cells (IC50 : 6.04 +/- 0.07, 40.78 +/- 4.28, and 10.57 +/- 0.51 mu g/ml, resp.). |
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