Organocatalytic Asymmetric Synthesis of Functionalized 4H-Chromenes via a One-Pot Domino Michael-Hemiacetalization and Dehydration Sequence

[摘要]：A one-pot thiourea-catalyzed enantioselective synthesis of polyfunctionalized 4H-chromenes via a domino Michael-hemiacetalization reaction and subsequent dehydration is reported. Starting from 2-nitrovinylphenols and beta-keto esters, the new protocol affords the 4H-chromenes bearing a variety of functional groups with good to excellent yields (76-95%) and enantioselectivities ranging from 30-99% ee. Both enantiomers are available at will depending on the ephedrine or pseudoephedrine-based thiourea catalyst used.

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