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[摘要]：A novel sp(2)-sp(3) diboron reagent has been developed for the copper-catalyzed beta-boration of alpha,beta-unsaturated conjugated compounds. The reaction proceeds under mild conditions with various substrates, i.e., alpha,beta-unsaturated esters, ketones, nitriles, ynones, amides, and aldehydes, in the absence of additives such as phosphine and sodium tert-butoxide to provide beta-borylhomoenolates in good to excellent yields. The presence of an sp(3)-hybridized boron center, un-ambigously confirmed by X-ray crystallography, sufficiently activates the unsymmetrical pinacolato diisopropanolaminato diboron (PDIPA diboron, 2) to transfer the sp(2)-hybridized boron moiety chemoselectively. These observations suggest that the activation of one of the boron atoms is an essential step in the Cu-catalyzed beta-boration catalytic cycle. |
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